CONTRAlNDlCATlONS

Hypersensitivity to the active substance or to any of the following list of excipients:

Sodium citrate

Citric acid monohydrate

Histidine

Histidine hydrochloride monohydrate

Sorbitol

Polysorbate 20

Water for injections

 

Active tuberculosis or other severe infections such as sepsis, and opportunistic infections. (see section 4.4 of the Summary of Product Characteristics).

 

Moderate to severe heart failure (NYHA class III/IV). (see section 4.4 of the Summary of Product Characteristics).