Hypersensitivity to the active substance or to any of the following list of excipients:
Citric acid monohydrate
Histidine hydrochloride monohydrate
Water for injections
Active tuberculosis or other severe infections such as sepsis, and opportunistic infections. (see section 4.4 of the Summary of Product Characteristics).
Moderate to severe heart failure (NYHA class III/IV). (see section 4.4 of the Summary of Product Characteristics).